Basic Information
VIS ID
TVIS10011763
Fusion event
HBV-BCYRN1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1750
Orient
-
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
70599160/71379310 (Hg38)
End
70599160/71379310 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
BCYRN1
Nearest miRNA
hsa-let-7f-2/Upstream/1356387; hsa-mir-105-1/Downstream/2839067;
Nearest TSS
ENST00000429181/Upstream/2303; ENST00000472567/Downstream/7776;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/12097, chrX-CpG: 80/Downstream/112889
Upstream sequence
TGTACATCAGCTAGCAGGTTGGCAGCAAGACCAATCCCAGGCTGTGGCTGCTGGAGGAACAGGAGAAATCATGGGTTTCTGCCTTGGCCAGCCCCAACTC
Downstream sequence
tctccatgttggtcaggcaggtctcgaactcccgacctcaggtgatcacccgcctcagcctcccaaagtgctgggattacaggtgtgagccaccacgccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate