VISDB Viral Integration Site DataBase

VIS ID

TVIS10011765

Fusion event

HBV-PHGDH integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1821

Orient

-

Integrated sequence

TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA

Chromosome

chr1

Cytoband

p12

Reference genome

Start

End

120281050/119738427 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-1229-3p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-107 ; hsa-mir-143-5p ; hsa-mir-759 ; hsa-mir-4519 ; hsa-mir-6499-3p ; hsa-mir-6792-5p ; hsa-mir-6733-3p ; hsa-mir-1178-5p ; hsa-mir-6801-5p ; hsa-mir-4257 ; hsa-mir-6847-5p

Nearest miRNA

hsa-mir-101-1/Upstream/2643699; hsa-mir-1182/Downstream/26112160;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/25778, chr1-CpG: 21/Downstream/114759

Upstream sequence

CCAGGCCTCTCTGCCCCCTCCATCCTGAGGAAAGAAGGGTGCCTCCTGCTGCCCAGCAGCCCCACACAGTCCATGGAAGTCAGCAGGGCTATGACCAGCA

Downstream sequence

GCATGCGAGGAGGTCAGCAGAGACTCTGACCTGTCTGCATCCTCTGTCCTCTATGCTGTGTGGGCTCCTCAGGGCAGAGCACACTTCACTCATCTTGCAC