Basic Information
VIS ID
TVIS10011767
Fusion event
HBV-AXDND1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1751
Orient
-
Integrated sequence
TTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGG| |AGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGT
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
179361858/179392723 (Hg38)
End
179361858/179392723 (Hg38)
Orient
+
Location type
Intronic
Target gene
AXDND1
Nearest miRNA
hsa-mir-101-1/Upstream/714889; hsa-mir-1182/Downstream/411201;
Nearest TSS
ENST00000473358/Upstream/23822; ENST00000484455/Downstream/98980;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/26520, chr1-CpG: 71/Downstream/182862
Upstream sequence
caagctgacatttatttttgattttttaaattatggccattcttgcagtagtagggtgatatttcattgtagttttaaattgcattttcttgataattag
Downstream sequence
tgatgttgagtattttttcatgtttgttgcctgtttgtatatcttcttttgaggattgtctattcatgtcctttgcccactttttggtgaaattatctgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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