Basic Information
VIS ID
TVIS10011768
Fusion event
HBV-AXDND1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2763
Orient
+
Integrated sequence
TTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATG| |GAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCT
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
179361881/179392746 (Hg38)
End
179361881/179392746 (Hg38)
Orient
-
Location type
Intronic
Target gene
AXDND1
Nearest miRNA
hsa-mir-101-1/Upstream/714912; hsa-mir-1182/Downstream/411178;
Nearest TSS
ENST00000473358/Upstream/23845; ENST00000484455/Downstream/98957;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/26543, chr1-CpG: 71/Downstream/182839
Upstream sequence
ttttaaattatggccattcttgcagtagtagggtgatatttcattgtagttttaaattgcattttcttgataattagtgatgttgagtattttttcatgt
Downstream sequence
ttgttgcctgtttgtatatcttcttttgaggattgtctattcatgtcctttgcccactttttggtgaaattatctgtttttttcttgctgatttgttgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate