VISDB Viral Integration Site DataBase

VIS ID

TVIS10011769

Fusion event

HBV-TP53BP2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1823

Orient

-

Integrated sequence

TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA

Chromosome

chr1

Cytoband

q41

Reference genome

Start

End

223971232/223783530 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-1301-3p ; hsa-mir-877-3p ; hsa-mir-222-3p ; hsa-mir-548d-3p ; hsa-mir-34a-5p

Nearest miRNA

hsa-mir-101-1/Upstream/3582911; hsa-mir-1182/Downstream/473510;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/34188, chr1-CpG: 138/Downstream/61853

Nearest cancer related gene

TP53BP2(TSG, No orient, 0)

Upstream sequence

AAACTTTTATCTCAATCTCTCGATTACCCTGATCATTTCTCTCACTCTTTCATACACCCTCCATGCCCCTTGCACACACACAACTGCTATAAGAGAACAG

Downstream sequence

CTGAATCTATAAAGAGCTTACTGCAAAGCCCTGGAATCTGTTATTCTCGCTTTCTCTCCTCTGTCTGACCATACGCCAGCCTTCCCCTGAAAATACTCCA