Basic Information
VIS ID
TVIS10011770
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
492
Orient
-
Integrated sequence
TTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGA| |TCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAA
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
End
248411799/248248497 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-101-1/Upstream/1046437; hsa-mir-3124/Downstream/577880;
Nearby gene
OR2M4(-8633) ; OR2T33(+24355) ;
Upstream sequence
CTTTGATGTGGTGCTCtatttttcaaaaattaaaaatttttaaaaGAAATATGGGTATTTCAGCAAaagaaaaaaagggagtgacagagggaggaaggga
Downstream sequence
ggaagaaacggaggaaaaagagaaACACTCCCCGAGATGCTTTCTTGCACATTATATTTTTCACTGTGGCTGTTCAATGGAGATGTCCCGAGGAAACCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate