Basic Information
VIS ID
TVIS10011771
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1629
Orient
-
Integrated sequence
ACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGC| |CCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAA
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
127581549/127711654 (Hg38)
End
127581549/127711654 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7a-2/Upstream/723112; hsa-mir-4697/Downstream/810736;
Nearest TSS
ENST00000527297/Upstream/440592; ENST00000609911/Downstream/468773;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/707740, chr11-CpG: 20/Downstream/740112
Nearby gene
KIRREL3-AS3(-705596) ; ETS1(+747107) ;
Nearest cancer related gene
ETS1(OG, +747107) ;
Upstream sequence
tacccctccctcccttgctaaccaccctttggattttcttccctaagggctaaacagaaactagcccattcaaaagacttcaccactgatatcaaccaat
Downstream sequence
gcctgatgctgcccctcttttttgccgttttcgcacaacaaccaaccaacggtccttcctgatgagagatcaccgaccatggaggggttctggccagtcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate