VISDB Viral Integration Site DataBase

VIS ID

TVIS10011773

Fusion event

HBV-SOX5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1825

Orient

+

Integrated sequence

TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA

Chromosome

chr12

Cytoband

p12.1

Reference genome

Start

End

24237524/24084590 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-194-5p ; hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-96-5p ; hsa-mir-130a-3p ; hsa-mir-181a-5p ; hsa-mir-132-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-1231 ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-4766-5p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-574-5p ; hsa-mir-5580-3p ; hsa-mir-555 ; hsa-mir-374a-3p ; hsa-mir-136-3p ; hsa-mir-4704-5p ; hsa-mir-3529-3p ; hsa-mir-6759-5p ; hsa-mir-6793-5p ; hsa-mir-6748-5p ; hsa-mir-933 ; hsa-mir-4783-5p ; hsa-mir-3607-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/6411196; hsa-let-7i/Downstream/127831;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/1459311, chr12-CpG: 92/Downstream/477432

Upstream sequence

AAATCCCTTATGTGTGATATTCTTTAAAATGAAATCTTAGTTTAAAAATAGTCCTCTATACATTTCATTTCAGAATCCATTATGTCAAGGGAAAATATTG

Downstream sequence

GAAGTAAAATATGAACATGGCACATTTCAACAATTCAAACGTCCACTACCAGTTACAATAACTTTGCTCTTGTTATCAGCTGTCAGCATTAGTTTCAAAA