Basic Information
VIS ID
TVIS10011775
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2650
Orient
+
Integrated sequence
TATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGG| |TTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATT
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
47315748/46921965 (Hg38)
End
47315748/46921965 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/4598106; hsa-let-7i/Downstream/265847;
Nearest TSS
ENST00000382841/Upstream/89557; ENST00000621214/Downstream/48539;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/90084, chr12-CpG: 94/Downstream/157429
Nearby gene
SLC38A4(-95968) ; AMIGO2(+153742) ;
Upstream sequence
AACTAGACTTCTAGACAaggaattgagaaatttttcctgtaaagagccagatagtaaatatttggggctttgtgaaccatatggtctctgttgcaaccac
Downstream sequence
ccaactctgctgttgtagcacaaaaacagcctggatgatacatcagcaaacgaatgtggctgtgctccaataaaactctattgctggatcctgaaactta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate