Basic Information
VIS ID
TVIS10011776
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1749
Orient
-
Integrated sequence
TCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGA| |GGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTT
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
47315776/46921993 (Hg38)
End
47315776/46921993 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/4598134; hsa-let-7i/Downstream/265819;
Nearest TSS
ENST00000382841/Upstream/89585; ENST00000621214/Downstream/48511;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/90112, chr12-CpG: 94/Downstream/157401
Nearby gene
SLC38A4(-95996) ; AMIGO2(+153714) ;
Upstream sequence
aatttttcctgtaaagagccagatagtaaatatttggggctttgtgaaccatatggtctctgttgcaaccacccaactctgctgttgtagcacaaaaaca
Downstream sequence
gcctggatgatacatcagcaaacgaatgtggctgtgctccaataaaactctattgctggatcctgaaacttaattttcatgtatcacaaaattttattct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate