Basic Information
VIS ID
TVIS10011778
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1460
Orient
-
Integrated sequence
ATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGAC| |CCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGC
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
84714462/84320683 (Hg38)
End
84714462/84320683 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/3162222; hsa-mir-1178/Downstream/2424385;
Nearest TSS
ENST00000382841/Upstream/36292; ENST00000393212/Downstream/547150;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1632816, chr12-CpG: 17/Downstream/590738
Nearby gene
TMTC2(-1186395) ; SLC6A15(+538805) ;
Upstream sequence
tacctaggaatccaacttacaagggatgtgaaggacctcttcaaggagaactacaaaccactgctcaacgaaaaaaaagacacaaacaaatggaagagca
Downstream sequence
ttccatgctcatggataggaagaatcaatatcatgaaaatggcatactgcccaaggtaatttacagattcaatgccatccccatcaagctaccaatgact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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