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Viral Integration Site DataBase
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TVIS10011781
Proximate region of VIS (GRCh38)
VIS
Enhancer
Enhancer/Promoter
Promoter
Gene
59990134
59893046
59950564
59859482
59892945
59891585
59894912
59874981
59875603
59885235
59885455
59890840
59890989
59899220
59899369
59914400
59914549
59910514
59910573
59924808
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011781
Fusion event
HBV-RPS6KB1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1711
Orient
-
Integrated sequence
GGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTC| |AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG
Host Sequence
Chromosome
chr17
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
58002169/59924808 (Hg38)
End
58002169/59924808 (Hg38)
Orient
+
Location type
Intronic
Target gene
RPS6KB1
miRNAs that regulate target gene
hsa-mir-215-5p
;
hsa-mir-192-5p
;
hsa-mir-103a-3p
;
hsa-mir-98-5p
;
hsa-mir-16-5p
;
hsa-mir-877-3p
;
hsa-mir-877-5p
;
hsa-mir-15a-5p
;
hsa-mir-107
;
hsa-mir-15b-5p
;
hsa-mir-195-5p
;
hsa-mir-424-5p
;
hsa-mir-497-5p
;
hsa-mir-548c-3p
;
hsa-mir-4668-3p
;
hsa-mir-5571-3p
;
hsa-mir-6838-5p
;
hsa-mir-1253
;
hsa-mir-3161
;
hsa-mir-145-5p
;
hsa-mir-138-2-3p
;
hsa-mir-451b
;
hsa-mir-599
;
hsa-mir-580-3p
;
hsa-mir-6770-5p
;
hsa-mir-500b-5p
;
hsa-mir-362-5p
;
hsa-mir-500a-5p
;
hsa-mir-455-5p
;
hsa-mir-200c-3p
;
hsa-mir-218-5p
;
hsa-mir-1271-3p
;
hsa-mir-4275
;
hsa-mir-550a-3-5p
;
hsa-mir-550a-5p
;
hsa-mir-550b-2-5p
Nearest miRNA
hsa-mir-10226/Upstream/83471; hsa-mir-1250/Downstream/118217;
Nearest TSS
ENST00000595228/Upstream/17820;
ENST00000587622/Downstream/6512;
Nearest CpG islands
None/Target,
chr17-CpG: 26/Upstream/31148
,
chr17-CpG: 23/Downstream/39677
Upstream sequence
tcatttcccctttcttgtacaaaagatagcatagtatccatgctgctgtacttttaagtactcttttgtatcttgtttttatagaaatttttcttatttt
Downstream sequence
tattttatttatttatttatttatttatttatttttttgagacggagtctcactttgtcacccaggctggagtgcagtggcgtgatctcggctcactgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Sample Information
×
Sample name
780P
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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