Basic Information
VIS ID
TVIS10011799
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1636
Orient
-
Integrated sequence
TTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAA| |ATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGG
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
112346532/111425376 (Hg38)
End
112346532/111425376 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/564729; hsa-mir-1243/Downstream/1222498;
Nearest TSS
ENST00000502981/Upstream/630973; ENST00000510034/Downstream/215119;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/785724, chr4-CpG: 120/Downstream/719938
Nearby gene
PITX2(-783253) ; FAM241A(+720021) ;
Nearest cancer related gene
PITX2(OG, -783253) ;
Upstream sequence
GTTTGGAACTACCAGCTAGATCTACTACCTAGGAAAAGCAGATTCTGTAGAATTCTATTTGTTTTAAAGAATTGAGGAAATTATTTGCCGTCACTCTAAA
Downstream sequence
aaattggcaagagtaaattcttacttatcaataataacatcaaatgtaagcccactaaactctccaatcaaaaggcatagactggctgaatggatgaaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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