Basic Information
VIS ID
TVIS10011801
Fusion event
HBV-LOC107986337 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1408
Orient
-
Integrated sequence
GGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCT| |GCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCG
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
189047481/188126327 (Hg38)
End
189047481/188126327 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986337
Nearest miRNA
hsa-mir-12113/Upstream/3187887;
Nearest TSS
ENST00000502981/Upstream/16724; ENST00000512233/Downstream/13092;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/19448, chr4-CpG: 33/Downstream/33367
Nearby gene
TRIML2(-21073) ; TRIML1(+13117) ;
Upstream sequence
tgataggagcaccaaccctattataaactgcatgtggaagtgatctaggttgtgtgctccttatgagaatctaatgcctgatgatctgtcactgtttccc
Downstream sequence
TGTGGTGAGGAGAAGCTGCAGCCTGTGACCCTGGACTCACTGAAGACTCCTCGTTAATCAAGCGGCCATCCTTATTCGGAAGAGCCCCAAGCATACTCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate