Basic Information
VIS ID
TVIS10011802
Fusion event
HBV-LINC02438 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
173
Orient
+
Integrated sequence
GTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATC| |AGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTC
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
19255689/19254066 (Hg38)
End
19255689/19254066 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LINC02438
Nearest miRNA
hsa-mir-12113/Upstream/5626109; hsa-mir-12115/Downstream/1274209;
Nearest TSS
ENST00000502981/Upstream/764558; ENST00000511431/Downstream/201370;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1231416, chr4-CpG: 284/Downstream/997587
Nearby gene
LCORL(-1232206) ; SLIT2(+999546) ;
Upstream sequence
atttagtgctataaatttccctctaaacactgctttagctgtgtctcagagattctggtatgttgtgtcttcattctcattggtttcaaatagcttattt
Downstream sequence
ATTTACAATCTGAAAGAGTTTTAACTGGGTTCCCAGGAGATTGGAAATATTTCTGTTTGTTGATGACATTTCCATTGAGATTCTAGAGCACCCACATTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate