Basic Information
VIS ID
TVIS10011805
Fusion event
HBV-LOC105377337 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
96482286/95561135 (Hg38)
End
96482286/95561135 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
LOC105377337
Nearest miRNA
hsa-mir-12113/Upstream/8260552; hsa-mir-1243/Downstream/3436252;
Nearest TSS
ENST00000502981/Upstream/11929; ENST00000295266/Downstream/278884;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/11292, chr4-CpG: 19/Downstream/2582316
Nearby gene
UNC5C(-11925) ; PDHA2(+278953) ;
Upstream sequence
ggccaaataaaacacagctgtgaactgctggccCCACCTCCCTACCAGGACTGCCGGTTTGCCCCCTCTGCTATGGAGTCTGCGATTTTGCCTTTTGGAC
Downstream sequence
TTTGAGCTGCAAAGTAAAAAATGAATGCTTTTCCTGGTAGCAACTTGTCTGATTGCTCTTCTTTGCATTTTATGTCATAATTTTCAAAACCTGAGCATCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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