Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011807
Fusion event
HBV-GHR integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
454
Orient
-
Integrated sequence
CCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACT| |ATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTAT
Host Sequence
Chromosome
chr5
Cytoband
p12
Reference genome
Start
End
42702063/42701961 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-10397/Upstream/4144400; hsa-mir-103a-1/Downstream/11249543;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/277016, chr5-CpG: 47/Downstream/222151
Upstream sequence
AATATTGAAGAGGAGGCTGAGTCCAGGCAAGAATTTGCTATACTTGCCTGCATAGGCAAGAGTGAAGGCCTGTACTTAAAAGAGGTGCAGTAGGTATGCA
Downstream sequence
ttgtgtacaacatatttttttgaaatatggatacattgtagaatggttctatcacactaagtaacatatgcattaccacacatacctttttttgtgtgtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.