Basic Information
VIS ID
TVIS10011809
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr5
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
63128000/63832173 (Hg38)
End
63128000/63832173 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/4128470; hsa-mir-103a-1/Downstream/8337294;
Nearest TSS
ENST00000502646/Upstream/1230944; ENST00000504296/Downstream/129960;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1418944, chr5-CpG: 32/Downstream/127044
Nearby gene
IPO11(-1203584) ; HTR1A(+127875) ;
Upstream sequence
tctggccccagccatctctccagcctcatttctgGTGACTCCCAGATCTGGCCCCAGCCATGTCTCTAGACTCCAAACTTATTCCTTATAATGCTCCCAC
Downstream sequence
TCTTCCATGAAACATTCCTAATGTCTTCAATTCCAATCATTTATTTCCCTAAATTTTCATTGTATTTAGATTCATAAAACCCAACAATTTTTTATTCTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate