VISDB Viral Integration Site DataBase

VIS ID

TVIS10011810

Fusion event

HBV-FRK integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1818

Orient

+

Integrated sequence

GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT

Chromosome

chr6

Cytoband

q22.1

Reference genome

Start

End

116416954/116095791 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-6867-5p ; hsa-mir-5682 ; hsa-mir-9-3p ; hsa-mir-6832-5p ; hsa-mir-4732-5p ; hsa-mir-6499-3p ; hsa-mir-5584-5p ; hsa-mir-4519 ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-6873-5p ; hsa-mir-4302 ; hsa-mir-6871-3p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4714-3p ; hsa-mir-6878-5p ; hsa-mir-6871-5p ; hsa-mir-4282 ; hsa-mir-1261 ; hsa-mir-151a-3p ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-4463 ; hsa-mir-4499 ; hsa-mir-1243 ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-6892-5p ; hsa-mir-203a-3p ; hsa-mir-6730-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-3974 ; hsa-mir-3646 ; hsa-mir-8077 ; hsa-mir-7160-5p ; hsa-mir-4663 ; hsa-mir-6761-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4728-3p ; hsa-mir-607 ; hsa-mir-4435 ; hsa-mir-488-3p ; hsa-mir-3671 ; hsa-mir-503-3p ; hsa-mir-31-5p ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-3190-5p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-3187-3p ; hsa-mir-4529-5p ; hsa-mir-5191 ; hsa-mir-6847-3p ; hsa-mir-490-5p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-4662a-5p ; hsa-mir-103b ; hsa-mir-3688-3p ; hsa-mir-8076 ; hsa-mir-450a-1-3p ; hsa-mir-2110 ; hsa-mir-6883-3p ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-4694-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-711 ; hsa-mir-4738-3p ; hsa-mir-454-5p ; hsa-mir-3938 ; hsa-mir-3654 ; hsa-mir-4661-5p ; hsa-mir-541-5p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4694-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-4529-3p ; hsa-mir-7850-5p ; hsa-mir-4520-2-3p ; hsa-mir-384 ; hsa-mir-7975 ; hsa-mir-4520-3p ; hsa-mir-5571-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p

Nearest miRNA

hsa-mir-10398/Upstream/9311571; hsa-mir-1202/Downstream/2973256;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/1752096, chr6-CpG: 74/Downstream/4719

Nearby gene

FRK(-35033) ; NT5DC1(+5045) ;

Nearest cancer related gene

FRK(TSG, No orient, 0)

Upstream sequence

tcccttgtgcaataggtttctggacttcttattgggtctcattggcatcttgcatattcttgggccgtcatctcactttcttaTTATACGCAGGAGACTA

Downstream sequence

ccaaggcctagacctcttcactgctgagaaaggaggactttgcagcttcttaggggaagagtgttgcttttacactaaccagtcagggacagtatgagat