MTSS1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011812
Fusion event
HBV-MTSS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3163
Orient
-
Integrated sequence
GCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCA| |TCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
125692380/124680139 (Hg38)
End
125692380/124680139 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
MTSS1
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-135a-5p ; hsa-mir-7111-3p ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193 ; hsa-mir-33a-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-96-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-12123/Upstream/171563; hsa-mir-10400/Downstream/141839;
Nearest TSS
ENST00000518652/Upstream/6626; ENST00000525292/Downstream/47477;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/140859, chr8-CpG: 161/Downstream/47305
Nearest cancer related gene
MTSS1(TSG, No orient, 0)
Upstream sequence
CCTTTGCTCAAAGACTGCTCCCTGTTCCCAATCTTCAGTTTAGGACATTGAAACTACTATTATATGTGGGTGGAAGTTATACTTGCACCCAAAGCATTTG
Downstream sequence
GCATGAAAGGCAGAATGGTTCTTCAAGATGAGATGTTTAAATGGCAACTTCTTTGTCACTGGATCAGACCACACATGTGGAACACAAGGGCTGTGTCCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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