Basic Information
VIS ID
TVIS10011813
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2122
Orient
-
Integrated sequence
GCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTG| |TTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTG
Host Sequence
Chromosome
chr8
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
66932661/66020426 (Hg38)
End
66932661/66020426 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNAJC5B ; LOC105375883
Nearest miRNA
hsa-mir-124-1/Upstream/1641169; hsa-mir-10400/Downstream/8528117;
Nearest TSS
ENST00000518652/Upstream/177674; ENST00000522619/Downstream/1134;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/177711, chr8-CpG: 23/Downstream/92684
Nearby gene
PDE7A(-178692) ; DNAJC5B(+1130) ;
Upstream sequence
CCTTTGCTCAAAGACTGCTCCCTGTTCCCAATCTTCAGTTTAGGACATTGAAACTACTATTATATGTGGGTGGAAGTTATACTTGCACCCAAAGCATTTG
Downstream sequence
ATGCAATACAGATACTTTTTAGTATCATATGGGGTTAGCGTCTAGAAAAAGTGAAGGGTATGAAATAATGAAGAATGAAATTCCAGTGAGACTCTATTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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