VISDB Viral Integration Site DataBase

VIS ID

TVIS10011817

Fusion event

HBV-OPCML integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1881

Orient

+

Integrated sequence

GCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTG| |TGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAG

Chromosome

chr11

Cytoband

q25

Reference genome

Start

End

133315069/133445174 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-3924 ; hsa-mir-8068 ; hsa-mir-190a-3p ; hsa-mir-567 ; hsa-mir-4307 ; hsa-mir-5011-5p

Nearest miRNA

hsa-let-7a-2/Upstream/2778371; hsa-mir-4697/Downstream/453330;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/83424, chr11-CpG: 23/Downstream/342554

Nearest cancer related gene

OPCML(TSG, No orient, 0)

Upstream sequence

CAAGAGACCACAGACCATATCCATGGTGATCCTGGATGGTGGATGGAGACCACCACACCCCATCTACACAATTTCAGGTATGAAAGGTCACCAAGAGACC

Downstream sequence

ACAGACCATATCCATGGTGATCCTGGATGGTGGATGGAGACCACCATAACCCATCTACACAATTTCAGGTATGAAAGGTCACCAAGAGACCACAGACCAA