Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011818
Fusion event
HBV-PLCL1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|
Start
1371
Orient
-
Integrated sequence
ACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGT| |TTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGG
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
End
198973674/198108950 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-599 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6844 ; hsa-mir-4775 ; hsa-mir-4778-3p ; hsa-mir-4735-5p ; hsa-mir-3692-3p ; hsa-mir-1236-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-3064-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-4727-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-140-3p ; hsa-mir-6728-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6873-3p ; hsa-mir-186-3p ; hsa-mir-4714-3p ; hsa-mir-4272 ; hsa-mir-3149 ; hsa-mir-374a-3p ; hsa-mir-361-5p ; hsa-mir-4328 ; hsa-mir-5094 ; hsa-mir-6768-5p
Nearest miRNA
hsa-mir-10b/Upstream/8975839; hsa-mir-1244-1/Downstream/8674284;
Nearest CpG islands
Upstream sequence
ATATCCAACTGTAGCAGTCAATTTGCTCTTCCTTTCTTTCTTTTTCACTATTGTACATGAAATTGGTCTCCTTACATAGCCATTGTGTTTATTTAGGATG
Downstream sequence
ATAGGATGATTCAGTCCTCACTACCTTTTCAAGACAATCACTGGATCAAAATAACTCCATTCCATTCCACCCTCACATGTTAAAAGACCTTTCCCTCTGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.