Basic Information
VIS ID
TVIS10011820
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
108077029/108741328 (Hg38)
End
108077029/108741328 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/7924763; hsa-mir-103a-1/Downstream/1772501;
Nearest TSS
ENST00000502646/Upstream/13068; ENST00000513676/Downstream/6494;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/12957, chr5-CpG: 110/Downstream/6958
Nearby gene
LINC01023(-13067) ; FER(+6494) ;
Upstream sequence
TCCCCAAATATTTGATAATTTCGCAAAAAAGTTTTCTCTTGCTAGTTATACATAAGATAGAATGTAGCTCTAGTATTGTCCAGTAATCACCCTGTTATCT
Downstream sequence
AGCAAAGATAAAACATTATTATTATTGACATATCCTttttttttctttttatcttatttttattttattagagacagtctcactttgtcacccaggctgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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