Basic Information
VIS ID
TVIS10011822
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2052
Orient
+
Integrated sequence
GTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCT| |CACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACC
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
102658932/102193376 (Hg38)
End
102658932/102193376 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1E
Nearest miRNA
hsa-mir-101-1/Upstream/1912068; hsa-mir-11399/Downstream/5703847;
Nearest TSS
ENST00000473358/Upstream/196346; ENST00000414923/Downstream/196254;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/956187, chr1-CpG: 85/Downstream/1332094
Nearby gene
OLFM3(-196142) ; COL11A1(+683091) ;
Upstream sequence
gtcgtgttgccaggctggtctcaaactcctgggctcaagtgatccacccacctcagcctcccaaagggctgggactataggcatgaaccaccacgaccag
Downstream sequence
cTGGAATGTGTTTTTCTATAACAAACATAGCTTTCACCCCATGCCCCTGACCTTAGGCTATCAAGGAATAATTAGTGTTTTAAAGTTGGGCTCTGTGACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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