Basic Information
VIS ID
TVIS10011826
Fusion event
HBV-MARC2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1830
Orient
-
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
220938477/220765135 (Hg38)
End
220938477/220765135 (Hg38)
Orient
-
Location type
Intronic
Target gene
MARC2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-6881-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-513b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/564516; hsa-mir-1182/Downstream/3491905;
Nearest TSS
ENST00000473358/Upstream/8857; ENST00000472447/Downstream/14827;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16580, chr1-CpG: 53/Downstream/21539
Upstream sequence
GTGTACACACTTAGAAGATACCAGAGATGTGTAGAAGTAGAACTACCTAAATCTGCCTGGAGAAGGGAGGCCTGGGCATGGGGAGGGGTCAGGTCCAGGT
Downstream sequence
CCCCGGAAGCAATGCTGTTCACCCTATACTTGTGTGGATTGTGTGCAGGCCAGGGTCAGAGGAGGGTCTTTATGGGTAAAGGTGACAGGCAGTTGGGAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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