Basic Information
VIS ID
TVIS10011828
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2389
Orient
+
Integrated sequence
CCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGC| |CTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTG
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
60686711/60221039 (Hg38)
End
60686711/60221039 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
LINC02778 ; LOC105378761
Nearest miRNA
hsa-mir-12136/Upstream/487743; hsa-mir-101-1/Downstream/1625036;
Nearest TSS
ENST00000473358/Upstream/106164; ENST00000496712/Downstream/375167;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/147171, chr1-CpG: 86/Downstream/821931
Nearby gene
C1orf87(-147269) ; NFIA(+856235) ;
Upstream sequence
TTGCTTCAACTTATTGGTTTAATTGTAGTCCTGAAGGTATATATCTATGAGGTCATGATTCTCACCTTGAAGAGGTGAAGGATGAGTTCCCCTTTCCTGG
Downstream sequence
AAAGTTTGTCATTCCTATTTGTATTTTCTGATCCACCAGAAAATGTAAGCACAAAAACACAAAATTGTGTAAAAGCATCAGTAAAATGTGAGTGGTGGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate