Basic Information
VIS ID
TVIS10011829
Fusion event
HBV-LOC107985037 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2255
Orient
+
Integrated sequence
TAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTA| |TTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGA
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
83863809/83398126 (Hg38)
End
83863809/83398126 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
LOC107985037
Nearest miRNA
hsa-mir-101-1/Upstream/6337924; hsa-mir-11399/Downstream/1735668;
Nearest TSS
ENST00000473358/Upstream/411918; ENST00000446227/Downstream/47841;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1594763, chr1-CpG: 50/Downstream/462458
Nearby gene
LPHN2(-1405702) ; MIR548AP(+395789) ;
Upstream sequence
TCTGTCCAAAGacaggtaatatccatgtaaaaattctcatattaacccaccaatgtccttcagcctgtgttgagaagcaccaactctcaggttgggggaa
Downstream sequence
tagtttatcctcccaggtccactcaattcttggcctataggctgagattgccacctagggagccaattagtgccaaatatgttggtggttttctgatgta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate