VISDB Viral Integration Site DataBase

VIS ID

TVIS10011830

Fusion event

HBV-WBP1L integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1828

Orient

+

Integrated sequence

AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT

Chromosome

chr10

Cytoband

q24.32

Reference genome

Start

End

104574031/102814274 (Hg38)

Orient

-

Location type

UTR3

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-19b-3p ; hsa-mir-760 ; hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-2110 ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-3153 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-582-3p

Nearest miRNA

hsa-mir-107/Upstream/377690; hsa-mir-1307/Downstream/579979;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/99320, chr10-CpG: 28/Downstream/39969

Upstream sequence

CTGCTGTTGAGCCAGAAGATGTCTCGTGTGAAGGCTGGGGTGGCGGCTGTCTTGGAACCTCTGTGAGCAGGAGGCCCTAAGCCGCAGCAGTGGATAGAGG

Downstream sequence

TGCAGCTCTCTGCCTCTCTGCCCTTTGGTCTGTGTTCACAGGTGACCCGTGTCAGCCTGCATCGCAAGCACACACCCTGCGGGCCTTCAAGTCTCACTGT