VISDB Viral Integration Site DataBase

VIS ID

TVIS10011831

Fusion event

HBV-WBP1L integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1442

Orient

-

Integrated sequence

TGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCG| |CTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACG

Chromosome

chr10

Cytoband

q24.32

Reference genome

Start

End

104574032/102814275 (Hg38)

Orient

+

Location type

UTR3

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-19b-3p ; hsa-mir-760 ; hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-2110 ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-3153 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-582-3p

Nearest miRNA

hsa-mir-107/Upstream/377691; hsa-mir-1307/Downstream/579978;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/99321, chr10-CpG: 28/Downstream/39968

Upstream sequence

TGCTGTTGAGCCAGAAGATGTCTCGTGTGAAGGCTGGGGTGGCGGCTGTCTTGGAACCTCTGTGAGCAGGAGGCCCTAAGCCGCAGCAGTGGATAGAGGT

Downstream sequence

GCAGCTCTCTGCCTCTCTGCCCTTTGGTCTGTGTTCACAGGTGACCCGTGTCAGCCTGCATCGCAAGCACACACCCTGCGGGCCTTCAAGTCTCACTGTT