Basic Information
VIS ID
TVIS10011835
Fusion event
HBV-CCDC58P2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1633
Orient
-
Integrated sequence
CTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCAC| |CAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACT
Host Sequence
Chromosome
chr10
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
52722861/50963101 (Hg38)
End
52722861/50963101 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
CCDC58P2
Nearest miRNA
hsa-mir-1265/Upstream/1977514; hsa-mir-107/Downstream/336472;
Nearest TSS
ENST00000439456/Upstream/77426; ENST00000561565/Downstream/1169;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/222840, chr10-CpG: 82/Downstream/28095
Nearby gene
A1CF(-77426) ; PRKG1(+28050) ;
Upstream sequence
GGAGGCTTGAAGTGAATTTGGCAGTATTCGTTAAACACCTTCCAGCTCCTTTCATTTACCACTCTTCAACATTCAGTTCTGACTGCATCCATTTCAACTT
Downstream sequence
TTTCTGCTCTTTTCTAAGTTGCTTTAATAATGTTAAATCATCCAAATTTTTATCTTTCTCTTCTTGGAAGTTTTTTACTACTGCTGTGGTCTGGACTATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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