Basic Information
VIS ID
TVIS10011838
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1700
Orient
-
Integrated sequence
GCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTG| |AGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
66918352/65158594 (Hg38)
End
66918352/65158594 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10C
Nearest miRNA
hsa-mir-1265/Upstream/1785546; hsa-mir-107/Downstream/2244757;
Nearest TSS
ENST00000439456/Upstream/24099; ENST00000428346/Downstream/155191;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/104291, chr10-CpG: 39/Downstream/2605491
Nearby gene
ANXA2P3(-331718) ; CTNNA3(+761373) ;
Nearest cancer related gene
CTNNA3(TSG, +761373) ;
Upstream sequence
caagaagatgagcaaaccccaaacaaaataaacccaatgaaatctatgccaagatatatcacacagaattacacttctaaaaaccaaagacaaatacaaa
Downstream sequence
aatatttaaagcagccagagaaaaataacatcttatctgtcagtaaaaaaatcaatttgaatgacagaaaatgttttatccgaaaccaagtaggtcagaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate