Basic Information
VIS ID
TVIS10011849
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
114086205/113648400 (Hg38)
End
114086205/113648400 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12E ; FRA12D
Nearest miRNA
hsa-let-7i/Upstream/356792; hsa-mir-1178/Downstream/2500160;
Nearest TSS
ENST00000382841/Upstream/176120; ENST00000550206/Downstream/118809;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/56453, chr12-CpG: 34/Downstream/317797
Nearby gene
LHX5(-176328) ; RBM19(+168338) ;
Upstream sequence
aGTGAACTTGGAAATCTTGGAGAAATAAATCATTTCCTCCTTAGCCTGACATCTCAGAGATTTGTCCAGCCTTAGATTGTAGCAGGAATAGGAAATTCCT
Downstream sequence
GATTTCAAAGCAGGAGTGAAAGAAGAAAGCTAGTATGTGGTTAAGAGTTTATATGTgccgggtgcagtggctcatgcctgtaatcccagctctttggaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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