Basic Information
VIS ID
TVIS10011850
Fusion event
HBV-LOC105370026 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2045
Orient
+
Integrated sequence
TACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTG| |TTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCT
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
119652539/119214734 (Hg38)
End
119652539/119214734 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
LOC105370026
Nearest miRNA
hsa-let-7i/Upstream/2786416; hsa-mir-1178/Downstream/498900;
Nearest TSS
ENST00000382841/Upstream/27934; ENST00000539847/Downstream/44283;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/60363, chr12-CpG: 19/Downstream/119814
Nearby gene
HSPB8(-19988) ; LINC00934(+69091) ;
Upstream sequence
GCAAATCTCCACTCTGCCTGAGTTCACATCTCCACTCTGTCAGAGTCCAAATCGTTACCCTGCCTGAGTGCAATTTCCAACCCTGcctaagtgcaaatcc
Downstream sequence
ccactctgccctcaactaactagaggatcttaggcaagtcacttcacctatccaaacctcagcatcgtcattagtaaaggggtaattttcattaccaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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