Basic Information
VIS ID
TVIS10011857
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr13
Cytoband
q14.12
Reference genome
GRCh37/hg19
Start
45389613/44815477 (Hg38)
End
45389613/44815477 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-2276/Upstream/619277; hsa-mir-1267/Downstream/5180938;
Nearest TSS
ENST00000623511/Upstream/5847; ENST00000611650/Downstream/174006;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/237325, chr13-CpG: 64/Downstream/173676
Nearby gene
LINC00330(-5847) ; NUFIP1(+123771) ;
Upstream sequence
TATGAGTATTGTGGAGGATGTGGAAAGCGTGGTCTGGTATAAGATCGCTGAACCAATGTTGAGTGTCACCGATGAATCTTCGCACCGTCCCTAGGTACCA
Downstream sequence
CTGGGCACCACACCAGGCCTAGGGTGACAAAAAAGGAGAAGATATATGTGGGGGAAAAGATAAAGAGACATGAAAGAAGAGAGGGCAAGAAAAAAGGGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate