Basic Information
VIS ID
TVIS10011860
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1761
Orient
-
Integrated sequence
GGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTT| |AAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTA
Host Sequence
Chromosome
chr13
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
67943693/67369561 (Hg38)
End
67943693/67369561 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/1151237; hsa-mir-1267/Downstream/10328451;
Nearest TSS
ENST00000623511/Upstream/139116; ENST00000415120/Downstream/2826;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/138234, chr13-CpG: 34/Downstream/1615211
Nearby gene
PCDH9(-139225) ; LINC00550(+1491724) ;
Nearest cancer related gene
PCDH9(TSG, -139225) ;
Upstream sequence
TGGTTTATAGCAGTAAAAGTTTACATAGAATTTAAATGTATTTAGTGTAATATTAATTATCATTATCATTCCCCCACCCAATCATAGTATTGATTAAGTC
Downstream sequence
TCTATTCAGGACTTAGTACTTCTACCCTGATTTTGTTCTCGTGTTCTTTTTTGTGTTAAATTCCTAGCTACGTTCCTTTCAATTAGGTTGACAGCCCCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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