Basic Information
VIS ID
TVIS10011863
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
32633779/32164573 (Hg38)
End
32633779/32164573 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/1149831; hsa-mir-1185-1/Downstream/4787736;
Nearest TSS
ENST00000550708/Upstream/10563; ENST00000557102/Downstream/164700;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/86638, chr14-CpG: 53/Downstream/36638
Nearby gene
ARHGAP5(-4845) ; AKAP6(+164700) ;
Upstream sequence
ctggcattcgccattagttttaatggtgaaaactgcaattgcttttgcctcaacctaaTACATAAGCAGACAGATCACCCACCACCACTACTCGTGTTTA
Downstream sequence
CCTCCCTCAGTTCACCCCTATGGTTGTATGAGGGGCCTCCTATGGTGAGATAAAGGAGGAGAAAAAGCCCAAGCTTGATTTACAAGAtgggaacatatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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