Basic Information
VIS ID
TVIS10011869
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
-
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr17
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
59614997/61537636 (Hg38)
End
59614997/61537636 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/1494531; hsa-mir-1250/Downstream/1406579;
Nearest TSS
ENST00000595228/Upstream/59273; ENST00000635817/Downstream/53566;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/75163, chr17-CpG: 21/Downstream/325828
Nearby gene
TBX4(-53333) ; NACA2(+52797) ;
Upstream sequence
aaacataaggacatgtatccaccattatagtaccatacagagtagtttccctgccctcaaattcccctgttctctacctatttgttcccccgtccccctc
Downstream sequence
aactcctggcaaccacttatcgatttactctctccgtagttttgccttttctggaatgtcgtatgattaaaatcaatacaAGCATActtcttttagttac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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