Basic Information
VIS ID
TVIS10011872
Fusion event
HBV-LOC101929650 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
+
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
81095195/83147426 (Hg38)
End
81095195/83147426 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101929650
Nearest miRNA
hsa-mir-10226/Upstream/479119;
Nearest TSS
ENST00000595228/Upstream/3295; ENST00000572850/Downstream/64570;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/11660, chr17-CpG: 81/Downstream/5058
Nearby gene
METRNL(-42604) ; RPL23AP87(+79471) ;
Upstream sequence
tgatggcatgtagaaatatagttgatttttgaaattgtgtatcctgtcatctggctaaacttgtttcttagtttcagttgtacttttggtggatttctta
Downstream sequence
gaattttgtgcaaaaagataactgcaaagagctttacttctctttttagcaatacagatgccttcattttattggttaccttgctgcattggctagaacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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