VISDB Viral Integration Site DataBase

VIS ID

TVIS10011873

Fusion event

HBV-PTPN2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2487

Orient

+

Integrated sequence

GCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTAC| |TGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAA

Chromosome

chr18

Cytoband

p11.21

Reference genome

Start

End

12846125/12846126 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-210-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-1264 ; hsa-mir-1202 ; hsa-mir-122-5p ; hsa-mir-1267 ; hsa-mir-129-5p ; hsa-mir-143-5p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-3652 ; hsa-mir-3672 ; hsa-mir-367-5p ; hsa-mir-3972 ; hsa-mir-431-5p ; hsa-mir-4423-5p ; hsa-mir-4430 ; hsa-mir-4755-3p ; hsa-mir-5006-5p ; hsa-mir-504-3p ; hsa-mir-5691 ; hsa-mir-5698 ; hsa-mir-6501-5p ; hsa-mir-6805-3p ; hsa-mir-6864-3p ; hsa-mir-744-3p ; hsa-mir-8055

Nearest miRNA

hsa-mir-3976/Upstream/1191185; hsa-mir-1-2/Downstream/613821;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/68012, chr18-CpG: 128/Downstream/37160

Nearest cancer related gene

PTPN2(TSG, No orient, 0)

Upstream sequence

ttgttttatagtgttcctccatttgagttgtcagatatctatttccctatagatgagttcagtttgtatatttttggcatgttcatctcagaaagatgct

Downstream sequence

aagtattcactgcatcttatcgggtggttcaggattctgacatggtatatctcatgactggtcatgaccacatatttaaggctggtgttggccagacttc