METTL4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011874
Fusion event
HBV-METTL4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1787
Orient
-
Integrated sequence
ACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTA| |GGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTT
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
2547648/2547649 (Hg38)
End
2547648/2547649 (Hg38)
Orient
-
Location type
Intronic
Target gene
METTL4
miRNAs that regulate target gene
hsa-mir-197-3p
Nearest miRNA
hsa-mir-8078/Upstream/2435310; hsa-mir-1-2/Downstream/1337704;
Nearest TSS
ENST00000575820/Upstream/58223; ENST00000575515/Downstream/7043;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1638076, chr18-CpG: 33/Downstream/23638
Upstream sequence
GGATGAGCAAAATTCACTGCAAAAGAAGAAAACTAAGCAGGGATAAGACATGCATAACACAGACTCCACAAATGCAAAGCTCTTACTGCTATTTATTTGT
Downstream sequence
GTAGCAAAATATAAAGCCACAGTGACACCCAGTGGACATATTATTACACACAAGACAAAAATCACCTTTTTTTTAACTAGTTTAAAATCGTCAGGCTGTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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