Basic Information
VIS ID
TVIS10011875
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1832
Orient
+
Integrated sequence
TGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCT| |CTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
4996411/4996412 (Hg38)
End
4996411/4996412 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-6718/Upstream/1110980; hsa-mir-1-2/Downstream/844283;
Nearest TSS
ENST00000575820/Upstream/541077; ENST00000583985/Downstream/8112;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/540765, chr18-CpG: 80/Downstream/199832
Nearby gene
DLGAP1(-541145) ; AKAIN1(+147261) ;
Upstream sequence
tagggaataatatcacagataacacagaaaaaaatgataacaagaaaatctttttaacaacataaggccaataaattcaacaacttagatgaaatagata
Downstream sequence
aatttcttgtcaattacaacttataaaaattgatatgtggagaaacagaatatatgattaaccttatatttagtaaataatggaagtcggccaggcccag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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