Basic Information
VIS ID
TVIS10011876
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1848
Orient
+
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCT| |TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTAC
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
54765826/57098595 (Hg38)
End
54765826/57098595 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA18B
Nearest miRNA
hsa-mir-1-2/Upstream/1619297; hsa-mir-122/Downstream/1352479;
Nearest TSS
ENST00000575820/Upstream/26476; ENST00000585477/Downstream/48403;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/447041, chr18-CpG: 24/Downstream/23133
Nearby gene
LINC-ROR(-26476) ; BOD1L2(+48467) ;
Upstream sequence
cccgtttcccaaaaacctatggaaacaaacaaaCAAAAAAAATTAAACAGTTATATTGCTTAAGACAGGAGGGAAAAGTGAGGGAGAGAAGTGAGACAGG
Downstream sequence
AAGCTGGAGGGGGACAAGGCAGAGCGCAAGGGGGGTACCAAGGAGAGGGGACATTTTCTTGGGGTAATGGGGTGTGTGTTTAAACAGGGGGGACCTGAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate