Basic Information
VIS ID
TVIS10011878
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2383
Orient
+
Integrated sequence
ACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTC| |CCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACT
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
5614071/5614072 (Hg38)
End
5614071/5614072 (Hg38)
Orient
+
Location type
Intronic
Target gene
EPB41L3 ; LOC100286986
miRNAs that regulate target gene
hsa-mir-223-3p ; hsa-mir-877-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-1305 ; hsa-mir-498 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-627-3p ; hsa-mir-4275 ; hsa-mir-5697 ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-4524b-3p ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-6718/Upstream/1728640; hsa-mir-1-2/Downstream/226623;
Nearest TSS
ENST00000575820/Upstream/36424; ENST00000580378/Downstream/14919;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/69830, chr18-CpG: 248/Downstream/14253
Nearby gene
EPB41L3(-70085) ; MIR3976HG(+134747) ;
Nearest cancer related gene
EPB41L3(TSG, No orient, 0)
Upstream sequence
tgcagttttcagttatctttgaggatgtatagaggtcctgagaccaaaacagttgagaacTAATAATCTAGAACACACAGCAGAAGGGCAAATGATACAA
Downstream sequence
GATGAGGCTGCAGAAATGGATGGGAGCAAACCATGTGGCCAAGGGAAGAATTCTGGTCTTTACCCAAGAGCAATGTTGGAATAGTCCACAGGTGTAGGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate