Basic Information
VIS ID
TVIS10011883
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
28773500/28282593 (Hg38)
End
28773500/28282593 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/7883239; hsa-let-7e/Downstream/6840107;
Nearest TSS
ENST00000633603/Upstream/217326; ENST00000592931/Downstream/30907;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/372668, chr19-CpG: 67/Downstream/444501
Nearby gene
LINC00662(-488652) ; LINC00906(+682538) ;
Upstream sequence
TCATCTCCCTTGTTGACTCCTTCCCAACCCCTCATCACAGTCTTCCCCCCACTGTCTTCTTCCCAACATTTTCTCCCCAGAATTTTATCTCCAGCTCCCC
Downstream sequence
CTCCACCATCTTCCCTGTACAGTGTTTTATCCCCACCCTCTCTTCCCGACCCACCCCCTTCTCCCCAGCCATCTTCTCCTGAACCACTTTCTCCTCACCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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