Basic Information
VIS ID
TVIS10011885
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2435
Orient
+
Integrated sequence
AGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATC| |TCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAAC
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
32768502/32277596 (Hg38)
End
32768502/32277596 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/11878242; hsa-let-7e/Downstream/2845104;
Nearest TSS
ENST00000633603/Upstream/171680; ENST00000587084/Downstream/67998;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/52812, chr19-CpG: 52/Downstream/67851
Nearby gene
THEG5(-684557) ; ZNF507(+68012) ;
Upstream sequence
aaggcaagattatgaacaacttaattctcgtatatttgacagtgtatatgaaatgaacagatttattgaggattttgattcatcaaaagggatattagaa
Downstream sequence
gaaatagaaaatctgtaaaagtcttaattccattaaagaagttgaatttgtaatcaaaagcaaacttgaggactaatggtttcactggtgaattctattg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate