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VISDB
Viral Integration Site DataBase
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TVIS10011886
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011886
Fusion event
HBV-PIN1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1622
Orient
-
Integrated sequence
GGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCG| |TGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTT
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
9952889/9842213 (Hg38)
End
9952889/9842213 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
PIN1
miRNAs that regulate target gene
hsa-mir-484
;
hsa-mir-324-5p
;
hsa-mir-200c-3p
;
hsa-mir-296-5p
;
hsa-mir-200b-3p
;
hsa-mir-4700-5p
;
hsa-mir-6796-5p
;
hsa-mir-4665-5p
;
hsa-mir-1275
;
hsa-mir-6788-5p
;
hsa-mir-30c-2-3p
;
hsa-mir-30c-1-3p
;
hsa-mir-6742-5p
;
hsa-mir-4472
;
hsa-mir-4447
;
hsa-mir-3151-5p
;
hsa-mir-491-5p
;
hsa-mir-5010-5p
;
hsa-mir-4525
;
hsa-mir-7111-5p
;
hsa-mir-6870-5p
;
hsa-mir-5698
;
hsa-mir-4723-5p
;
hsa-mir-625-5p
;
hsa-mir-486-3p
;
hsa-mir-6721-5p
;
hsa-mir-5187-5p
;
hsa-mir-8085
;
hsa-mir-6731-5p
;
hsa-mir-6878-5p
;
hsa-mir-1255b-5p
;
hsa-mir-1255a
;
hsa-mir-744-5p
;
hsa-mir-6775-5p
;
hsa-mir-5090
;
hsa-mir-199b-5p
;
hsa-mir-199a-5p
;
hsa-mir-4302
;
hsa-mir-6871-5p
;
hsa-mir-4733-5p
;
hsa-mir-2392
;
hsa-mir-4781-5p
;
hsa-mir-6859-5p
;
hsa-mir-3916
;
hsa-mir-3125
;
hsa-mir-4320
;
hsa-mir-873-5p
;
hsa-mir-3605-5p
;
hsa-mir-3679-5p
;
hsa-mir-1185-5p
;
hsa-mir-6870-3p
;
hsa-mir-140-5p
;
hsa-mir-874-3p
;
hsa-mir-574-3p
;
hsa-mir-6501-3p
;
hsa-mir-8485
Nearest miRNA
hsa-mir-1227/Upstream/1452833; hsa-let-7e/Downstream/196141;
Nearest TSS
ENST00000633603/Upstream/3614;
ENST00000592332/Downstream/15933;
Nearest CpG islands
None/Target,
chr19-CpG: 112/Upstream/6500
,
chr19-CpG: 38/Downstream/12055
Nearest cancer related gene
PIN1
(TSG, No orient, 0)
Upstream sequence
ACCTGGTGGAAGCTGTGGGAGGAATTGGAGCAAGAGGCGGTGTGACTTGAACTTGGGGGCTGGAAGTGGAAGAAGAAGTGAGAGGGAGCAGACCCGAGAG
Downstream sequence
AGATTCAGGAGGCAGGATAGAGAGGACTGGGTGATGGATTAGGTGGGCAAGGGTGGGATGTCTGGGGGAGGGTCAGGGCAGAACAGCGTGGCCCACcctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Sample Information
×
Sample name
781P
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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