Basic Information
VIS ID
TVIS10011894
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1711
Orient
-
Integrated sequence
GGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTC| |AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
76868620/76641494 (Hg38)
End
76868620/76641494 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/1550580; hsa-mir-10b/Downstream/3007800;
Nearest TSS
ENST00000437798/Upstream/922374; ENST00000445178/Downstream/344471;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/930481, chr2-CpG: 32/Downstream/2351572
Nearby gene
GCFC2(-930509) ; LRRTM4(+106230) ;
Upstream sequence
aggtaatacatgcaaaatatataaataaacagaaagagggctggcctacagtaagtgttcaataTTTCTACCTATAGTTTTTATTAGCTATTTTTGTCTA
Downstream sequence
TTCTAGTCCTGGTCATAACGTATGAAAAGATAAAcctggcacaacgcttggtgcaaagatggtgctcagaaaatgttgattgaattaatTTTCTCCTGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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