Basic Information
VIS ID
TVIS10011898
Fusion event
HBV-LOC105373490 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1773
Orient
-
Integrated sequence
TCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGT| |ACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCT
Host Sequence
Chromosome
chr2
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
96307338/95641590 (Hg38)
End
96307338/95641590 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105373490
Nearest miRNA
hsa-mir-1285-2/Upstream/6829136; hsa-mir-10b/Downstream/1156688;
Nearest TSS
ENST00000437798/Upstream/49572; ENST00000425887/Downstream/24494;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/224, chr2-CpG: 22/Downstream/7657
Nearby gene
TRIM43(-41869) ; FAHD2CP(+368961) ;
Upstream sequence
tcaagtagatcacagagtctatttttcccatactgatgtctctgtgtgttcaatgcttagctcccaattataagtgagaacatacagcatttaattttct
Downstream sequence
gattctgcattaatttgcttaggatcacagcctccagctccatccccattgctgtaagagaGTTGGTGTGCCCAGAGTAAAGCCCTCCATTTAAGCTCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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