Basic Information
VIS ID
TVIS10011904
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2066
Orient
+
Integrated sequence
ACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACT| |CAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTAT
Host Sequence
Chromosome
chr20
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
21474157/21493519 (Hg38)
End
21474157/21493519 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/3022828; hsa-mir-1-1/Downstream/4714667;
Nearest TSS
ENST00000382410/Upstream/94626; ENST00000549659/Downstream/9415;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/95912, chr20-CpG: 158/Downstream/11775
Nearby gene
NKX2-4(-96110) ; NKX2-2(+17503) ;
Upstream sequence
TCCAAATGTCTTCTTATGAAAATCAGGGCCATCGTTATTTTCCTTGTGGATTTTGAATAACTCATAGTTCTTAGGTAGACTTGACCCTTTCACAGGAAGT
Downstream sequence
TTTTTCTTATAAAGCCTCTTATATTTTAGGGTGGAAGATTGCTCAGTCCTCCATCTCTTGGGTAAACAACCCACATCACACCTGGGCCATGTTTCTTTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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